Objective To analyze the clinical efficacy of endovenous laser treatment combined with  transilluminated powered phlebectomy for great saphenous varicosity and summarize the experiencein order to achieve better results. Methods From January 2014 to June 2015, 45 patients (52 limbs,including 17 males and 28 females, aged 36 to 68 years) diagnosed as great saphenous varicosity received endovenous laser treatment combined with transilluminated powered phlebectomy. Thirty-eight cases was unilateral great saphenous varicose veins, 7 cases was bilateral large saphenous varicose veins. The clinical efficacy was analyzed. Results All cases were performed successfully. The mean operation time was （68.4±15.1） minutes, the average bleeding volume was （23.5±10.7） ml, the number of mean operative incision quantity was （5.8±1.9）and the average hospitalization time was （5.9±1.6） days. All patients had no serious complications. During a mean follow-up time of 22 months (12 to 30 months)，only one patient recurred. Conclusions Endovenous laser treatment combined with transilluminated powered phlebectomy for great saphenous varicosity is effective and safe. It also has the advantages of shorter operation time, less bleeding, shorter hospitalization time, small trauma and better cosmetic results.