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外泌体miRNA在乳腺癌早期诊断和早期筛查中的应用
作者: 陈乐天  周冬仙  颜晨
Authors: Chen Letian, Zhou Dongxian, Yan Chen
单位: 深圳市人民医院(暨南大学第二临床医学院)甲状腺乳腺外科518020
Units: Department of Thyroid and Breast Surgery, Shenzhen People′s Hospital (the Second Clinical Medical College of Jinan University), Shenzhen 518020, China
关键词: 乳腺肿瘤;早期诊断;外泌体;微RNAs
Keywords: Breast neoplasms;Early diagnosis;Exosomes;MicroRNAs
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出版年,卷(期):页码:2020,47(1):48-54
摘要:

 乳腺癌在女性恶性肿瘤中发病率最高,治疗的关键在于早期诊断和早期治疗。目前乳腺癌的早期诊断主要依靠影像学检查,临床普遍缺乏一种能用于乳腺癌早期诊断的方法。外泌体是乳腺肿瘤细胞向外周循环选择性释放并稳定存在一定时间的小分子物质,它所含的miRNA是一种短的、非编码的调节性RNA,能够通过结合到目标mRNA的3′UTR区域并调节目标mRNA的转录后表达,从而影响乳腺癌的发生、发展。外泌体miRNA能够提示乳腺癌细胞的存在、临床分期、分子分型等多种信息,可能在未来投入临床应用,成为乳腺癌早期诊断的理想标志物。本文就外泌体miRNA在乳腺癌早期诊断中的研究及应用进展作一综述。

 Breast cancer is the most common malignant tumor in women. The key to the prognosis of breast cancer lies in early diagnosis and early treatment.At present, the early diagnosis of breast cancer mainly relies on imaging methods, and there has been a lack of clinical methods for early diagnosis of it.Exosome are small molecules selectively released from breast cancer cells to the peripheral circulation for a certain period of time. miRNA contained in them are short, noncoding regulatory RNA, which can bind to the 3′UTR region of target genes and regulate the posttranscriptional expression of target genes. Exogenous miRNA can affect the development of  breast cancer,  It can provide a variety of information indicating the presence of breast cancer cells, clinical staging, molecular typing and other information, which may be put into clinical application in the future as an ideal marker for the early diagnosis of breast cancer.This article reviews the research and application of exogenous miRNA in early diagnosis of breast cancer.

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