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肝移植术后肝缺血再灌注损伤保护作用的研究进展
作者: 龙昊陈雅峻龚建平2
Authors: Long Hao1,   Chen Yajun2,   Gong Jianping2
单位: 1重庆市大足区人民医院肝胆外科 402360;2重庆医科大学附属第二医院肝外科 400010 通信作者:龚建平,Email: gongjianping11@126.com
Units: 1Department of Hepatobiliary Surgery, the Dazu District People′s Hospital, Chongqing 402360, China; 2Department of Hepatobiliary Surgery, the Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China Corresponding author: Gong Jianping, Email: gongjianping11@126.com
关键词: 再灌注损伤;NF-κB;肝移植
Keywords: Reperfusion injury; NF-kappa B; Liver transplantation
分类号:
出版年,卷(期):页码:2020,47(3):212-216
摘要:

 肝缺血再灌注损伤是肝移植术后最常见的并发症。活性氧生成过多导致的氧化应激、自噬、炎症反应是造成肝缺血再灌注损伤的重要步骤。其中,核转录因子红系2相关因子2被认为是抗氧化反应的主要调节因子,PI3K-Akt-mTOR通路被认为是自噬的重要通路,HMGB1-TLR4-NF-κB通路被认为是导致炎症的关键信号通路,本文将从上述通路及调节分子出发,分别从基因、分子、药物等方面研究对肝缺血再灌注细胞的抗氧化、抗炎、调节自噬作用,探究对肝缺血再灌注细胞的保护作用。

 Hepatic ischemia-reperfusion injury is the most common complication after liver transplantation. Oxidative stress, autophagy, and inflammatory response caused by excessive reactive oxygen species production are significant steps that cause liver ischemia-reperfusion injury. What′s more, nuclear factor erythroid 2-related factor 2 is considered to be a major regulator of the antioxidant response, the PI3K-Akt-mTOR signaling pathway is considered to be an important pathway of autophagy, and the HMGB1-TLR4-NF-κB signaling pathway is considered to be a key signaling pathway which leads to inflammation. Based on the above signaling pathways and regulatory factor, this article shows that the antioxidant, anti-inflammatory and autophagy regulation effects of genes, molecules and drugs on hepatic ischemia-reperfusion cells, to explore the protective effects on hepatic ischemia-reperfusion cells.

基金项目:
国家自然科学基金资助项目(81670599)
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